Genetic evidences in neurodegenerations and oxidative stress oxidative stress related neurodegeneration is not only caused by disturbed metal metabolism but genetic evidences suggests that persons associated with certain types of genetic mutations are more susceptible to gain neurological pathological compare to normal to those with normal . Here we review the role of mitochondrial oxidative stress in the aging process with a specific focus on neurodegenerative diseases understanding the molecular mechanisms involving mitochondria and oxidative stress in the aging and neurodegeneration may help to identify new strategies for improving the health and extending lifespan. Disease alzheimers disease friedreichs ataxia and amyotrophic lateral sclerosis may involve the generation of reactive oxygen species and mitochondrial dysfunction here we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders. How can oxidative stress or its effects be attenuated do antioxidants prevent or slow the progress of the disease is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age related neurodegeneration some chapters look at the various ways research is getting to the core of neurodegenerative . Alzheimer disease ad is a major cause of age related dementia we do not fully understand ad aetiology and pathogenesis but oxidative damage is a key component the brain mostly uses glucose
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